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Effect of Image-Guidance Frequency on Geometric Accuracy and Setup Margins in Radiotherapy for Locally Advanced Lung Cancer by Jane Higgins; Andrea Bezjak; Andrew Hope; Tony Panzarella; Winnie Li; John B.C. Cho; Tim Craig; Anthony Brade; Alexander Sun; Jean-Pierre Bissonnette is a Medicine article available to read on EtoBox.
What is Effect of Image-Guidance Frequency on Geometric Accuracy and Setup Margins in Radiotherapy for Locally Advanced Lung Cancer about?
## Purpose: To assess the relative effectiveness of five image-guidance (ig) frequencies on reducing patient positioning inaccuracies and setup margins for locally advanced lung cancer patients. ## Methods and materials: Daily cone-beam computed tomography data for 100 patients (4,237 scans) were analyzed. subsequently, four less-than-daily ig protocols were simulated using these data (no ig, first 5-day ig, weekly ig, and alternate-day ig). the frequency and magnitude of residual setup error were determined. the less-than-daily ig protocols were compared against the daily ig, the assumed reference standard. finally, the population-based setup margins were calculated. ## Results: With the less-than-daily ig protocols, 20-43% of fractions incurred residual setup errors ≥ 5 mm; daily ig reduced this to 6%. with the exception of the first 5-day ig, reductions in systematic error (∑) occurred as the imaging frequency increased and only daily ig provided notable random error (σ) reductions (∑ = 1.5-2.2 mm, σ = 2.5-3.7 mm; ∑ = 1.8-2.6 mm, σ = 2.5-3.7 mm; and ∑ = 0.7-1.0 mm, σ = 1.7-2.0 mm for no ig, first 5-day ig, and daily ig, respectively. an overall significant difference in the mean
Who reads Effect of Image-Guidance Frequency on Geometric Accuracy and Setup Margins in Radiotherapy for Locally Advanced Lung Cancer?
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- Author
- Jane Higgins; Andrea Bezjak; Andrew Hope; Tony Panzarella; Winnie Li; John B.C. Cho; Tim Craig; Anthony Brade; Alexander Sun; Jean-Pierre Bissonnette
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)