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Can I read Cystathionine β-Synthase as a Carbon Monoxide–sensitive Regulator of Bile Excretion on EtoBox?
Cystathionine β-Synthase as a Carbon Monoxide–sensitive Regulator of Bile Excretion by Tsunehiro Shintani; Takuya Iwabuchi; Tomoyoshi Soga; Yuichiro Kato; Takehiro Yamamoto; Naoharu Takano; Takako Hishiki; Yuki Ueno; Satsuki Ikeda; Tadayuki Sakuragawa; Kazuo Ishikawa; Nobuhito Goda; Yuko Kitagawa; Mayumi Kajimura; Kenji Matsumoto; Makoto Suematsu is a Medicine article available to read on EtoBox.
What is Cystathionine β-Synthase as a Carbon Monoxide–sensitive Regulator of Bile Excretion about?
Carbon monoxide (CO) is a stress-inducible gas generated by heme oxygenase (HO) eliciting adaptive responses against toxicants; however, mechanisms for its reception remain unknown. Serendipitous observation in metabolome analysis in CO-overproducing livers suggested roles of cystathionine -synthase (CBS) that rate-limits transsulfuration pathway and H 2 S generation, for the gas-responsive receptor. Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it. The CO-overproducing livers down-regulated H 2 S to stimulate HCO 3 ؊ -dependent choleresis: these responses were attenuated by blocking HO or by donating H 2 S. Livers of heterozygous CBS knockout mice neither down-regulated H 2 S nor exhibited the choleresis while overproducing CO. In the mouse model of estradiol-induced cholestasis, CO overproduction by inducing HO-1 significantly improved the bile output through stimulating HCO 3 ؊ excretion; such a choleretic response did not occur in the knockout mice. Conclusion: Results collected from metabolome a
Who reads Cystathionine β-Synthase as a Carbon Monoxide–sensitive Regulator of Bile Excretion?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tsunehiro Shintani; Takuya Iwabuchi; Tomoyoshi Soga; Yuichiro Kato; Takehiro Yamamoto; Naoharu Takano; Takako Hishiki; Yuki Ueno; Satsuki Ikeda; Tadayuki Sakuragawa; Kazuo Ishikawa; Nobuhito Goda; Yuko Kitagawa; Mayumi Kajimura; Kenji Matsumoto; Makoto Suematsu
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)