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Atypical Alzheimer Disease Variants by Angelina J. Polsinelli; Liana G. Apostolova is a Medicine article available to read on EtoBox.

What is Atypical Alzheimer Disease Variants about?

## ABSTRACT ## PURPOSE OF REVIEW This article discusses the clinical, neuroimaging, and biomarker profiles of sporadic atypical Alzheimer disease (AD) variants, including early-onset AD, posterior cortical atrophy, logopenic variant primary progressive aphasia, dysexecutive variant and behavioral variant AD, and corticobasal syndrome. ## RECENT FINDINGS Significant advances are being made in the recognition and characterization of the syndromically diverse AD variants. These variants are identified by the predominant cognitive and clinical features: early-onset amnestic syndrome, aphasia, visuospatial impairments, dysexecutive and behavioral disturbance, or motor symptoms. Although understanding of regional susceptibility to disease remains in its infancy, visualizing amyloid and tau pathology in vivo and CSF examination of amyloid-β and tau proteins are particularly useful in atypical AD, which can be otherwise prone to misdiagnosis. Large-scale research efforts, such as LEADS (the Longitudinal Early-Onset Alzheimer Disease Study), are currently ongoing and will continue to shed light on our understanding of these diverse presentations. ## SUMMARY Understanding the clinical, neuro

Who reads Atypical Alzheimer Disease Variants?

Author

Angelina J. Polsinelli; Liana G. Apostolova

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2022

Language

EN

Field

Medicine (Health Sciences)