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Defining a Valid Age Cutoff in Staging of Well-Differentiated Thyroid Cancer by Nixon, Iain J.; Kuk, Deborah; Wreesmann, Volkert; Morris, Luc; Palmer, Frank L.; Ganly, Ian; Patel, Snehal G.; Singh, Bhuvanesh; Tuttle, R. Michael; Shaha, Ashok R.; Gönen, Mithat; Shah, Jatin P. is a Medicine article available to read on EtoBox.
What is Defining a Valid Age Cutoff in Staging of Well-Differentiated Thyroid Cancer about?
## Background: Age 45 years is used as a cutoff in the staging of well-differentiated thyroid cancer (wdtc) as it represents the median age of most datasets. the aim of this study was to determine a statistically optimized age threshold using a large dataset of patients treated at a comprehensive cancer center. ## Methods: Overall, 1807 patients with a median follow-up of 109 months were included in the study. recursive partitioning was used to determine which american joint committee on cancer (ajcc) variables were most predictive of disease-specific death, and whether a different cutoff for age would be found. from the resulting tree, a new age cutoff was picked and patients were restaged using this new cutoff. ## Results: The 10-year disease-specific survival (dss) by union for international cancer control (ajcc/uicc) stage was 99.6, 100, 96, and 81 % for stages i-iv, respectively. using recursive partitioning, the presence of distant metastasis was the most powerful predictor of dss. for m0 patients, age was the next most powerful predictor, with a cutoff of 56 years. for m1 patients, a cutoff at 54 years was most predictive. having reviewed the analysis, age 55 years was selec
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- Author
- Nixon, Iain J.; Kuk, Deborah; Wreesmann, Volkert; Morris, Luc; Palmer, Frank L.; Ganly, Ian; Patel, Snehal G.; Singh, Bhuvanesh; Tuttle, R. Michael; Shaha, Ashok R.; Gönen, Mithat; Shah, Jatin P.
- Publisher
- Springer; Springer - Society of Surgical Oncology; Springer New York LLC; Springer Science and Business Media LLC (ISSN 1068-9265)
- Published
- 2015
- Language
- EN
- ISBN
- 9781043401542
- Field
- Medicine (Health Sciences)