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Correlation of ADCC Activity With Cytokine Release Induced by The Stably Expressed Glyco-Engineered Humanized Lewis Y-Specific Monoclonal Antibody MB by dhrgham711 is a document available to read on EtoBox.

What is Correlation of ADCC Activity With Cytokine Release Induced by The Stably Expressed Glyco-Engineered Humanized Lewis Y-Specific Monoclonal Antibody MB about?

The study investigates the correlation between antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine release induced by the glyco-engineered humanized monoclonal antibody MB314, which targets the Lewis Y antigen. Results indicate that MB314 exhibits a significantly enhanced ADCC activity (up to 40-fold) compared to its parental antibody MB311, while also inducing the release of immunostimulatory cytokines such as TNF and IL-6. The findings suggest that glyco-engineering can improve the therapeut

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dhrgham711

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EN