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Can I read Mass Transfer and Rheological Characteristics in a Stirred Tank Bioreactor for Cultivation of Escherichia coli BL21 on EtoBox?
Mass Transfer and Rheological Characteristics in a Stirred Tank Bioreactor for Cultivation of Escherichia coli BL21 by Sohail Rasool Lone; Vimal Kumar; Jeffrey R. Seay; Derek L. Englert; Hyun Tae Hwang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mass Transfer and Rheological Characteristics in a Stirred Tank Bioreactor for Cultivation of Escherichia coli BL21 about?
With the rapid growth of pharmaceutical and biotechnology industry, stirred tank bioreactors have received much attention due to simple design, easy control of operating conditions, and low operating cost. In the development of commercial processes, however, a transition from laboratory to industrial scale faces great challenges because many properties related to size change nonlinearly as a system increases. In this context, along with an understanding of fluid dynamics, application of an efficient method for scale-up is critical for designing successful industrial process. Particularly in cell cultivation processes, it is important to evaluate the oxygen transfer and viscous properties of liquid medium. In the present study, the effect of various key operating variables such as agitation rate and aeration rate, impeller diameter, and bioreactor working volume for different impellers on the volumetric mass transfer coefficient (k L a) have been investigated in a stirred tank bioreactor for cultivating Escherichia coli BL21. It was found that the k L a tends to increase with the operating variables except the bioreactor working volume. Among the tested impellers, the pitched blade
Who reads Mass Transfer and Rheological Characteristics in a Stirred Tank Bioreactor for Cultivation of Escherichia coli BL21?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sohail Rasool Lone; Vimal Kumar; Jeffrey R. Seay; Derek L. Englert; Hyun Tae Hwang
- Publisher
- The Korean Society for Biotechnology and Bioengineering; Springer-Verlag; Korean Society for Biotechnology and Bioengineering; Springer Science and Business Media LLC (ISSN 1226-8372)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)