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Can I read Association analysis of the dopamine D~2~ receptor gene in Tourette's syndrome using the haplotype relative risk method on EtoBox?
Association analysis of the dopamine D~2~ receptor gene in Tourette's syndrome using the haplotype relative risk method by Markus M. Nöthen; Johannes Hebebrand; Michael Knapp; Kathrin Hebebrand; Astrid Camps; Alexander von Gontard; Roswitha Wettke‐Schäfer; Sonja Lisch; Sven Cichon; Fritz Poustka; Martin Schmidt; Gerd Lehmkuhl; Helmut Remschmidt; Peter Propping is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Association analysis of the dopamine D~2~ receptor gene in Tourette's syndrome using the haplotype relative risk method about?
## Abstract Comings et al. [1991: JAMA 266: 1793–1800] have recently reported a highly significant association between Tourette's syndrome (TS) and a restriction fragment length polymorphism (RFLP) of the dopamine D~2~ receptor gene (DRD2) locus. The A1 allele of the DRD2 __Taq__ I RFLP was present in 45% of the Tourette patients compared with 25% of controls. We tried to replicate this finding by using the haplotype relative risk (HRR) method for association analysis. This method overcomes a major problem of conventional case‐control studies, where undetected ethnic differences between patients and controls may result in a false‐positive finding, by using parental alleles not inherited to the proband as control alleles. Sixtyone nuclear families encompassing an affected child and parents were typed for the DRD2 __Taq__ I polymorphism. No significant differences in DRD2 A1 allele frequency were observed between TS probands, subpopulations of probands classified according to tic severity, or parental control alleles. Our data do not support the hypothesis that the DRD2 locus may act as a modifying gene in the expression of the disorder in TS probands. © 1994 Wiley‐Liss, Inc.
Who reads Association analysis of the dopamine D~2~ receptor gene in Tourette's syndrome using the haplotype relative risk method?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Markus M. Nöthen; Johannes Hebebrand; Michael Knapp; Kathrin Hebebrand; Astrid Camps; Alexander von Gontard; Roswitha Wettke‐Schäfer; Sonja Lisch; Sven Cichon; Fritz Poustka; Martin Schmidt; Gerd Lehmkuhl; Helmut Remschmidt; Peter Propping
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 1994
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)