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Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori -infection by Nader Bagheri; Alireza Razavi; Batoul Pourgheysari; Fatemeh Azadegan-Dehkordi; Ghorbanali Rahimian; Ashkan Pirayesh; Mohammedhadi Shafigh; Mahmoud Rafieian-Kopaei; Rana Fereidani; Kamran Tahmasbi; Hedayatollah Shirzad is a Medicine article available to read on EtoBox.
What is Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori -infection about?
## Background: During helicobacter pylori (h. pylori) infection cd4 t cells in the gastric lamina propria are hyporesponsive and polarized by th1/th17 cell responses controlled by treg cells. the objective of this study was to determine the number of th17 cells in gastric mucosa of patients with gastritis and peptic ulcer and determined the relationship between main virulence factor of h. pylori and th17 cells. ## Methods and materials: A total of 89 h. pylori-infected gastritis patients, 63 h. pylori-infected peptic ulcer patients and 48 h. pylori-negative non-ulcer dysplasia patients were enrolled in this study. the number of th17 was determined by immunohistochemistry. il-8 and il-17a expressions were determined by real-time polymerase chain reaction (qpcr). also, the grade of chronic and active inflammation was investigated for involvement according to the density of neutrophils and mononuclear in gastric mucosal crypts, from one to all crypts. ## Results: The number of th17 cells and the expression of il-8 and il-17a in infected patients were significantly higher than uninfected subjects. the number of th17 cells and the expression of il-8 and il-17a in infected patients with
Who reads Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori -infection?
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- Author
- Nader Bagheri; Alireza Razavi; Batoul Pourgheysari; Fatemeh Azadegan-Dehkordi; Ghorbanali Rahimian; Ashkan Pirayesh; Mohammedhadi Shafigh; Mahmoud Rafieian-Kopaei; Rana Fereidani; Kamran Tahmasbi; Hedayatollah Shirzad
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)