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Multi-session electrical neuromodulation effects on craving, relapse and cognitive functions in cocaine use disorder: A randomized, sham-controlled tDCS study by Ilse Verveer; Frederik M. van der Veen; Alireza Shahbabaie; Danielle Remmerswaal; Ingmar H.A. Franken is a Medicine article available to read on EtoBox.

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## Background: The use of transcranial direct current stimulation (tdcs) has previously shown promising results for reducing craving in cocaine use disorder. in this study we further explored the potential of tdcs as add-on intervention in the treatment of cocaine use disorder. ## Methods: In a randomized, placebo-controlled, between subject study, we applied tdcs bilaterally with the anodal electrode targeting the right dorsolateral prefrontal cortex (dlpfc; https://clinicaltrials.gov/ct2/show/nct03025321). patients with cocaine use disorder were allocated to ten sessions of either active tdcs (n = 29) or sham (n = 30) on five consecutive days. inhibitory control and risky decision-making were measured via a go-nogo task and a two-choice gambling task, respectively, each at baseline, one day after all tdcs sessions and after three months. relapse at follow-up and craving were also assessed. ## Results: There was no significant effect of active tdcs on the number of cocaine use days and craving. relapse was frequent among patients who had received either active or sham tdcs (48.0 % and 69.2 %, respectively), despite an overall decrease in craving during the first two weeks of treat

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Author

Ilse Verveer; Frederik M. van der Veen; Alireza Shahbabaie; Danielle Remmerswaal; Ingmar H.A. Franken

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0376-8716)

Published

2020

Language

EN

Field

Medicine (Health Sciences)