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The use of p16/Ki-67 dual staining technology on cervical cytology of patients undergoing a LLETZ procedure by Bram, Packet; Willy, Poppe; Birgit, Weynand; Miet, Vanherck is a Medicine article available to read on EtoBox.

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## Objectives: The main objective of this prospective observational study was to investigate the diagnostic performance of the p16/ki-67 dual stain technique (dst) for detecting cin 2+ in a lletz referral setting. test performances were compared with hr-hpv testing and pap cytology. ## Methods: All patients referred for a lletz procedure were candidates for participation in this trial. a total of 110 patients were enrolled between october 2016 and march 2017. from each participant, a cervical cytology sample was obtained before the onset of the lletz procedure. on each sample, the dual stain technique (roche cintec plus ® test), pap cytology and an hpv dna assay (identifying 17 different hpv types) were performed. ## Results: The overall disease prevalence of cin 2+ was 56%. the mean age was 41 years, with 38% of patients being younger than 35 years. the overall sensitivity and specificity of the dual stain technique for detecting cin 2+ was 94% (95% ci: 84.30-98.21%) and 58% (95% ci: 43.21-72.93%) respectively with a ppv of 74% (95% ci: 67.34-80.31%) and a npv of 88% (95% ci: 72.48-94.90%). hr-hpv testing results in a similar sensitivity of 92% (95% ci: 82.17-97.33%) but considera

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Author

Bram, Packet; Willy, Poppe; Birgit, Weynand; Miet, Vanherck

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-2115)

Published

2018

Language

EN

Field

Medicine (Health Sciences)