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The study investigates the use of the P2X7 receptor as a novel drug delivery system to enhance the entry of the hydrophilic drug methylene blue (MB) into cells during photodynamic therapy (PDT). Results show that combining MB with ATP significantly increases its cytoplasmic entry in cells expressing P2X7R, suggesting that this receptor could facilitate the delivery of hydrophilic drugs in cancer treatments. The findings indicate potential improvements in PDT efficacy by utilizing the P2X7R-associated pore f

Author

Paulo Pacheco

Language

EN