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Can I read The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells on EtoBox?
The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells by E. Martín-Montañez; J. Pavia; N. Valverde; F. Boraldi; E. Lara; B. Oliver; I. Hurtado-Guerrero; O. Fernandez; M. Garcia-Fernandez is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells about?
Fingolimod is one of the few oral drugs available for the treatment of multiple sclerosis (MS), a chronic, inflammatory, demyelinating and neurodegenerative disease. The mechanism of action proposed for this drug is based in the phosphorylation of the molecule to produce its active metabolite fingolimod phosphate (FP) which, in turns, through its interaction with S1P receptors, triggers the functional sequestration of T lymphocytes in lymphoid nodes. On the other hand, part if not most of the damage produced in MS and other neurological disorders seem to be mediated by reactive oxygen species (ROS), and mitochondria is one of the main sources of ROS. In the present work, we have evaluated the anti-oxidant profile of FP in a model of mitochondrial oxidative damage induced by menadione (Vitk3) on neuronal cultures. We provide evidence that incubation of neuronal cells with FP alleviates the Vitk3-induced toxicity, due to a decrease in mitochondrial ROS production. It also decreases regulated cell death triggered by imbalance in oxidative stress (restore values of advanced oxidation protein products and total thiol levels). Also restores mitochondrial function (cytochrome c oxidase ac
Who reads The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- E. Martín-Montañez; J. Pavia; N. Valverde; F. Boraldi; E. Lara; B. Oliver; I. Hurtado-Guerrero; O. Fernandez; M. Garcia-Fernandez
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)