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Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer) by Kézia O. A. L. Lins; Daniel P. Bezerra; Ana Paula N. N. Alves; Nylane M. N. Alencar; Michael W. Lima; Valeska M. Torres; Wladimir R. L. Farias; Cláudia Pessoa; Manoel O. de Moraes; Letícia V. Costa‐Lotufo is a Environmental Science article available to read on EtoBox.
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## Abstract In recent years, much attention has been focused on polysaccharides isolated from natural sources. The aim of this study was to investigate the __in vitro__ and __in vivo__ antitumor properties of a sulfated polysaccharide isolated from the seaweed __C__. __feldmannii__ (Cf‐PLS). Hematological, biochemical and histopathological analyses were performed in order to evaluate the toxicological aspects related to Cf‐PLS treatment. Its effects on the immunological system were also investigated. The Cf‐PLS did not show any significant __in vitro__ cytotoxicity at the experimental exposure levels that were used, but showed __in vivo__ antitumor effect. The inhibition rates of sarcoma 180 tumor development were 48.62 and 48.16% at the doses of 10 and 25 mg kg^−1^, respectively. In addition, Cf‐PLS was also able to increase the response elicited by 5‐fluorouracil (5‐FU) from 48.66 to 68.32%. The histopathological analysis of liver and kidney showed that both organs were moderately affected by Cf‐PLS‐treatment. Neither enzymatic activity of alanine aminotransferase nor urea or creatinine levels were significantly altered. In hematological analysis, leucopeny was observed after 5‐F
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- Author
- Kézia O. A. L. Lins; Daniel P. Bezerra; Ana Paula N. N. Alves; Nylane M. N. Alencar; Michael W. Lima; Valeska M. Torres; Wladimir R. L. Farias; Cláudia Pessoa; Manoel O. de Moraes; Letícia V. Costa‐Lotufo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)
- Published
- 2008
- Language
- EN
- Field
- Environmental Science (Physical Sciences)