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Plasma Concentrations of Ropivacaine Following a Single-shot Caudal Block of 1, 2 or 3 Mg/kg in Children by A. T. Bösenberg; J. Thomas; T. Lopez; G. Huledal; L. Jeppsson; L. E. Larsson is a Medicine article available to read on EtoBox.

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**Background:** For documenting the properties of ropivacaine used for regional anaesthesia in children, the relationship between dose and resulting systemic exposure is essential. The aim of this pharmacokinetic part of a randomised, multicentre, double‐blind study was to determine the free and total plasma levels of ropivacaine in children aged between 4 and 12 years following a single‐shot caudal dose of 1, 2 or 3 mg/kg of ropivacaine for postoperative pain management. **Method:** Following induction of a standardised general anaesthetic (halothane; nitrous oxide: oxygen 60:40), a caudal block using 1 ml/kg ropivacaine in concentrations of 1, 2 or 3 mg/ml was performed in 43 ASA I children (body weight 12–25 kg) scheduled for elective inguinal surgery. Blood samples were collected prior to and 15, 30, 45, 60 and 240 min after placement of the caudal block for determination of total and free ropivacaine plasma concentrations. **Results:** The peak plasma concentration of total ropivacaine, reached within 15–241 min after the block, increased in proportion to dose, with mean values at 0.27, 0.64 and 0.90 mg/l following 1, 2 and 3 mg/kg respectively. The peak plasma level of free r

Who reads Plasma Concentrations of Ropivacaine Following a Single-shot Caudal Block of 1, 2 or 3 Mg/kg in Children?

Author

A. T. Bösenberg; J. Thomas; T. Lopez; G. Huledal; L. Jeppsson; L. E. Larsson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-5172)

Published

2001

Language

EN

Field

Medicine (Health Sciences)