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Can I read Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures on EtoBox?
Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures by Korbinian Brunner; Johannes Harder; Tobias Halbach; Julian Willibald; Fabio Spada; Felix Gnerlich; Konstantin Sparrer; Andreas Beil; Leonhard Möckl; Christoph Bräuchle; Karl-Klaus Conzelmann; Thomas Carell is a Chemistry article available to read on EtoBox.
What is Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures about?
We report the development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand. The nanoparticles elicit strong siRNA responses, despite the dendritic structure. An siRNA dendrimer directed against the crucial rabies virus (RABV) nucleoprotein (N protein) and phosphoprotein (P protein) allowed the suppression of the virus titer in neurons below the detection limit. The cell-penetrating siRNA dendrimers, which were assembled using click chemistry, open up new avenues toward finding novel molecules able to cure this deadly disease.
Who reads Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Korbinian Brunner; Johannes Harder; Tobias Halbach; Julian Willibald; Fabio Spada; Felix Gnerlich; Konstantin Sparrer; Andreas Beil; Leonhard Möckl; Christoph Bräuchle; Karl-Klaus Conzelmann; Thomas Carell
- Publisher
- Wiley
- Published
- 2014
- Language
- EN
- Field
- Chemistry (Physical Sciences)