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GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms by Yuli T. Magalhaes; Jessica O. Farias; Luiz E. Silva; Fabio L. Forti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms about?

The classical small Rho GTPase (Rho, Rac, and Cdc42) protein family is mainly responsible for regulating cell motility and polarity, membrane trafficking, cell cycle control, and gene transcription. Cumulative recent evidence supports important roles for these proteins in the maintenance of genomic stability. Indeed, DNA damage response (DDR) and repair mechanisms are some of the prime biological processes that underlie several disease phenotypes, including genetic disorders, cancer, senescence, and premature aging. Many reports guided by different experimental approaches and molecular hypotheses have demonstrated that, to some extent, direct modulation of Rho GTPase activity, their downstream effectors, or actin cytoskeleton regulation contribute to these cellular events. Although much attention has been paid to this family in the context of canonical actin cytoskeleton remodeling, here we provide a contextualized review of the interplay between Rho GTPase signaling pathways and the DDR and DNA repair signaling components. Interesting questions yet to be addressed relate to the spatiotemporal dynamics of this collective response and whether it correlates with different subcellular

Who reads GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms?

Author

Yuli T. Magalhaes; Jessica O. Farias; Luiz E. Silva; Fabio L. Forti

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)