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Can I read Phage Engineering and the Evolutionary Arms Race on EtoBox?
Phage Engineering and the Evolutionary Arms Race by Peng, Huan; Chen, Irene A is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Phage Engineering and the Evolutionary Arms Race about?
Phages are versatile agents for delivering a variety of cargo, including nanomaterials, nucleic acids, and small molecules. A potentially important application is treatment of antibiotic-resistant infections. All of these applications require molecular engineering of the phages, including chemical modification and genetic engineering. Phages are remarkably amenable to such engineering. We review some examples, including for controlled phage therapy. We suggest that the ability of phages to support extensive engineering may have evolutionary origins in the billions-year-old 'arms race' between bacteria and phages, which selects for sequences and structures that are robust in the face of rapid evolutionary change. This leads to high tolerance of both naturally evolved mutations and synthetic molecular engineering.
Who reads Phage Engineering and the Evolutionary Arms Race?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Peng, Huan; Chen, Irene A
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0958-1669)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)