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A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) by Roberto Romero; Lara A. Friel; Digna R. Velez Edwards; Juan Pedro Kusanovic; Sonia S. Hassan; Shali Mazaki-Tovi; Edi Vaisbuch; Chong Jai Kim; Offer Erez; Tinnakorn Chaiworapongsa; Brad D. Pearce; Jacquelaine Bartlett; Benjamin A. Salisbury; Madan Kumar Anant; Gerald F. Vovis; Min Seob Lee; Ricardo Gomez; Ernesto Behnke; Enrique Oyarzun; Gerard Tromp; Scott M. Williams; Ramkumar Menon is a Medicine article available to read on EtoBox.

What is A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) about?

## Objective: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (snps) in candidate genes are associated with preterm prelabor rupture of membranes (pprom). ## Study design: A case-control study was conducted in patients with pprom (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 snps were studied. single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q\* = 0.15). ## Results: First, a snp in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pprom (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; p = .000068), and this association remained significant after correction for multiple comparisons. second, haplotypes for alpha 3 type iv collagen isoform precursor in the mother were associated with pprom (global p = .003). third, multilocus analysis identified a 3-locus model, which included maternal snps in collagen type i alpha 2, defensin alpha 5 gene, and endothelin 1. ## Conclusion: Dna variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pprom.

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Author

Roberto Romero; Lara A. Friel; Digna R. Velez Edwards; Juan Pedro Kusanovic; Sonia S. Hassan; Shali Mazaki-Tovi; Edi Vaisbuch; Chong Jai Kim; Offer Erez; Tinnakorn Chaiworapongsa; Brad D. Pearce; Jacquelaine Bartlett; Benjamin A. Salisbury; Madan Kumar Anant; Gerald F. Vovis; Min Seob Lee; Ricardo Gomez; Ernesto Behnke; Enrique Oyarzun; Gerard Tromp; Scott M. Williams; Ramkumar Menon

Publisher

Elsevier BV

Published

2010

Language

EN

Field

Medicine (Health Sciences)