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Can I read SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence on EtoBox?
SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence by Sen Ye; Yan-Fu Ding; Wen-Huan Jia; Xiao-Li Liu; Jing-Yi Feng; Qian Zhu; Sun-Li Cai; Yao-Shun Yang; Qian-Yun Lu; Xue-Ting Huang; Jin-Shu Yang; Sheng-Nan Jia; Guo-Ping Ding; Yue-Hong Wang; Jiao-Jiao Zhou; Yi-Ding Chen; Wei-Jun Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence about?
Quiescent cancer stem cells (CSC) play important roles in tumorigenesis, relapse, and resistance to chemoradiotherapy. However, the determinants of CSC quiescence and how they sustain themselves to generate tumors and relapse beyond resistance to chemoradiotherapy remains unclear. Here, we found that SET domain-containing protein 4 (SETD4) epigenetically controls breast CSC (BCSC) quiescence by facilitating heterochromatin formation via H4K20me3 catalysis. H4K20me3 localized to the promoter regions and regulated the expression of a set of genes in quiescent BCSCs (qBCSC). SETD4-defined qBCSCs were resistant to chemoradiotherapy and promoted tumor relapse in a mouse model. Upon activation, a SETD4-defined qBCSC sustained itself in a quiescent state by asymmetric division and concurrently produced an active daughter cell that proliferated to produce a cancer cell population. Single-cell sequence analysis indicated that SETD4 qBCSCs clustered together as a distinct cell type within the heterogeneous BCSC population. SETD4-defined quiescent CSCs were present in multiple cancer types including gastric, cervical, ovarian, liver, and lung cancers and were resistant to chemotherapy. SETD4-
Who reads SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sen Ye; Yan-Fu Ding; Wen-Huan Jia; Xiao-Li Liu; Jing-Yi Feng; Qian Zhu; Sun-Li Cai; Yao-Shun Yang; Qian-Yun Lu; Xue-Ting Huang; Jin-Shu Yang; Sheng-Nan Jia; Guo-Ping Ding; Yue-Hong Wang; Jiao-Jiao Zhou; Yi-Ding Chen; Wei-Jun Yang
- Publisher
- American Association for Cancer Research (AACR)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)