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Differentiated Expression of Somatostatin Receptor Subtypes in Experimental Models and Clinical Neuroblastoma by Kleopatra Georgantzi; Apostolos V. Tsolakis; Mats Stridsberg; Åke Jakobson; Rolf Christofferson; Eva Tiensuu Janson is a Medicine article available to read on EtoBox.

What is Differentiated Expression of Somatostatin Receptor Subtypes in Experimental Models and Clinical Neuroblastoma about?

## Abstract ## Background Neuroblastoma (NB) is a solid tumor of childhood originating from the adrenal medulla or sympathetic nervous system. Somatostatin (SS) is an important regulator of neural and neuroendocrine function, its actions being mediated through five specific membrane receptors. The aim of this study was to investigate the expression of the different somatostatin receptors (SSTRs) in NB tumor cells that may form targets for future therapeutic development. ## Procedure Tumor specimens from 11 children with stage II–IV disease were collected before and/or after chemotherapy. Experimental tumors derived from five human NB cell lines were grown subcutaneously in nude mice. Expression of SSRTs, the neuroendocrine marker chromogranin A (CgA) and SS was detected by immunohistochemistry using specific antibodies. ## Results SSTR2 was detected in 90%, SSTR5 in 79%, SSTR1 in 74%, SSTR3 in 68% whereas SSTR4 was expressed in 21% of the clinical tumors. The experimental tumors expressed SSTRs in a high but variable frequency. All clinical tumors showed immunoreactivity for CgA but not for SS. ## Conclusion The frequent expression of SSTRs indicates that treatment with unlabeled o

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Author

Kleopatra Georgantzi; Apostolos V. Tsolakis; Mats Stridsberg; Åke Jakobson; Rolf Christofferson; Eva Tiensuu Janson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2010

Language

EN

Field

Medicine (Health Sciences)