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Can I read Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus on EtoBox?
Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus by Isokawa, Masako; Alger, Bradley E. is a Neuroscience article available to read on EtoBox.
What is Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus about?
Endogenous cannabinoids (eCBs) are produced and mobilized in a cytosolic calcium ([Ca^2+^]~i~)–dependent manner, and they regulate excitatory and inhibitory neurotransmitter release by acting as retrograde messengers. An indirect but real-time bioassay for this process on GABAergic transmission is DSI (depolarization-induced suppression of inhibition). The magnitude of DSI correlates linearly with depolarization-induced increase of [Ca^2+^]~i~that is thought to be initiated by Ca^2+^influx through voltage-gated Ca^2+^channels. However, the identity of Ca^2+^sources involved in eCB mobilization in DSI remains undetermined. Here we show that, in CA1 pyramidal cells, DSI-inducing depolarizing voltage steps caused Ca^2+^-induced Ca^2+^release (CICR) by activating the ryanodine receptor (RyR) Ca^2+^-release channel. CICR was reduced, and the remaining increase in [Ca^2+^]~i~was less effective in generating DSI, when the RyR antagonists, ryanodine or ruthenium red, were applied intracellularly, or the Ca^2+^stores were depleted by the Ca^2+^-ATPase inhibitors, cyclopiazonic acid or thapsigargin. The CICR-dependent effects were most prominent in cultured or immature acute slices, but were
Who reads Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Isokawa, Masako; Alger, Bradley E.
- Publisher
- The American Physiological Society; American Physiological Society (ISSN 0022-3077)
- Published
- 2006
- Language
- EN
- Field
- Neuroscience (Life Sciences)