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Suspended sediment exacerbates perfluorooctane sulfonate mediated toxicity through reactive oxygen species generation in freshwater clam Corbicula fluminea by Yan Liu; Muhammad Junaid; Peng Xu; Wei Zhong; Baozhu Pan; Nan Xu is a Environmental Science article available to read on EtoBox.

What is Suspended sediment exacerbates perfluorooctane sulfonate mediated toxicity through reactive oxygen species generation in freshwater clam Corbicula fluminea about?

Perfluorooctane sulfonate (PFOS) potentially adsorbs on the surface of suspended sediment (SPS), which can develop a toxic "pool" bioavailable to benthic organisms. In this study, the freshwater clam Corbicula fluminea was employed as a zoobenthos model to study the effects of SPS (collected from the Yellow River) on the bioaccumulation and toxicity (from the molecular level to cellular and physiological levels) caused by PFOS exposure. Besides, the enhanced integrated biomarker response (EIBR) system was applied as an index to evaluate the in-depth toxic effects of PFOS and SPS single and co-exposure at various treatment levels. Our results demonstrated that PFOS-SPS co-exposure (at sub-lethal doses of PFOS) significantly increased the bioaccumulation of PFOS, and induced the elevated levels of reactive oxygen species (ROS), the significantly increased activities of superoxide dismutase (SOD) and catalase (CAT) enzymes, the significantly increased content of malondialdehyde (MDA), and the significantly upregulated expression levels of sod, selenium-dependent glutathione peroxidase (se-gpx), heat shock protein 22 (hsp22), heat shock protein 40 (hsp40) and cytochrome P450 30 (cyp30)

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Author

Yan Liu; Muhammad Junaid; Peng Xu; Wei Zhong; Baozhu Pan; Nan Xu

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV; Publons (ISSN 0269-7491)

Published

2020

Language

EN

Field

Environmental Science (Physical Sciences)