Can I read The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE on EtoBox?

The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE by David S. Pisetsky is a Medicine article available to read on EtoBox.

What is The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE about?

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti‐DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti‐DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provoke nephritis and stimulation of cytokine production following uptake into innate immune cells and interaction with internal nucleic acid sensors. These sensors are part of an internal host defense system in the cell cytoplasm that can respond to DNA from infecting organisms; during cell stress, DNA from nuclear and mitochondrial sources can also trigger these sensors. The formation of immune complexes requires a source of extracellular DNA in an immunologically accessible form. As shown in __in vivo__ and __in vitro__ systems, extracellular DNA can emerge from dead

Who reads The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE?

Author

David S. Pisetsky

Publisher

Wiley

Published

2024

Language

EN

Field

Medicine (Health Sciences)