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The bone formation in vitro and mandibular defect repair using PLGA porous scaffolds by Tianbin Ren; Jie Ren; Xiaozhen Jia; Kefeng Pan is a Engineering article available to read on EtoBox.

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## Abstract Highly porous scaffolds of poly(lactide‐__co__‐glycolide) (PLGA) were prepared by solution‐casting/salt‐leaching method. The __in vitro__ degradation behavior of PLGA scaffold was investigated by measuring the change of normalized weight, water absorption, pH, and molecular weight during degradation period. Mesenchymal stem cells (MSCs) were seeded and cultured in three‐dimensional PLGA scaffolds to fabricate __in vitro__ tissue engineering bone, which was investigated by cell morphology, cell number and deposition of mineralized matrix. The proliferation of seeded MSCs and their differentiated function were demonstrated by experimental results. To compare the reconstructive functions of different groups, mandibular defect repair of rabbit was made with PLGA/MSCs tissue engineering bone, control PLGA scaffold, and blank group without scaffold. Histopathologic methods were used to estimate the reconstructive functions. The result suggests that it is feasible to regenerate bone tissue __in vitro__ using PLGA foams with pore size ranging from 100–250 μm as scaffolding for the transplantation of MSCs, and the PLGA/MSCs tissue engineering bone can greatly promote cell growth

Who reads The bone formation in vitro and mandibular defect repair using PLGA porous scaffolds?

Author

Tianbin Ren; Jie Ren; Xiaozhen Jia; Kefeng Pan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2005

Language

EN

Field

Engineering (Physical Sciences)