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A Role for Neutrophils in Early Enthesitis in Spondyloarthritis by Zheni Stavre; Charles Bridgewood; Qiao Zhou; Yukiko Maeda; Ting-ting Huang; Jozsef Karman; Almas Khan; Sami Giryes; Kassem Sharif; Dennis McGonagle; Ellen M. Gravallese is a Medicine article available to read on EtoBox.

What is A Role for Neutrophils in Early Enthesitis in Spondyloarthritis about?

## Abstract ## Background Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unknown. We considered the role of neutrophils in the experimental SKG mouse model of SpA and in human axial entheses. ## Methods Early inflammatory infiltrates in the axial and peripheral entheseal sites in SKG mice were evaluated using immunohistochemistry and laser capture microdissection of entheseal tissue. Whole transcriptome analysis was carried out using Affymetrix gene array MTA 1.0, and data was analyzed via IPA. We further isolated neutrophils from human peri-entheseal bone and fibroblasts from entheseal soft tissue obtained from the axial skeleton of healthy patients and determined the response of these cells to fungal adjuvant. ## Results Following fungal adjuvant administration, early axial and peripheral inflammation in SKG mice was characterized by prominent neutrophilic entheseal inflammation. Expression of transcripts arising from neutrophils include abundant mRNA for the alarmins S100A8 and S100A9. In normal human axial entheses, neutro

Who reads A Role for Neutrophils in Early Enthesitis in Spondyloarthritis?

Author

Zheni Stavre; Charles Bridgewood; Qiao Zhou; Yukiko Maeda; Ting-ting Huang; Jozsef Karman; Almas Khan; Sami Giryes; Kassem Sharif; Dennis McGonagle; Ellen M. Gravallese

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)