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Can I read Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives on EtoBox?
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives by Takeshi Honda; Takeshi Masuda; Shuku Yoshida; Masami Arai; Yoshiyuki Kobayashi; Makoto Yamashita is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives about?
Substitution of 7-OH by small hydrophobic groups on zanamivir resulted in the retaining of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. These compounds were prepared by treatment of the corresponding 7-substituted sialic acids derived from 4-modified N-acetyl-D-mannosamine (ManNAc) using enzyme-catalyzed aldol condensation.
Who reads Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Takeshi Honda; Takeshi Masuda; Shuku Yoshida; Masami Arai; Yoshiyuki Kobayashi; Makoto Yamashita
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)