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Functional diversification of cell signaling by GPCR localization by Matthew J. Klauer; Blair K.A. Willette; Nikoleta G. Tsvetanova is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Functional diversification of cell signaling by GPCR localization about?

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and a critical class of regulators of mammalian physiology. Also known as seven transmembrane receptors (7TMs), GPCRs are ubiquitously expressed and versatile, detecting a diverse set of endogenous stimuli, including odorants, neurotransmitters, hormones, peptides, and lipids. Accordingly, GPCRs have emerged as the largest class of drug targets, accounting for upward of 30% of all prescription drugs. The view that ligand-induced GPCR responses originate exclusively from the cell surface has evolved to reflect accumulating evidence that receptors can elicit additional waves of signaling from intracellular compartments. These events in turn shape unique cellular and physiological outcomes. Here, we discuss our current understanding of the roles and regulation of compartmentalized GPCR signaling.

Who reads Functional diversification of cell signaling by GPCR localization?

Author

Matthew J. Klauer; Blair K.A. Willette; Nikoleta G. Tsvetanova

Publisher

American Society for Biochemistry and Molecular Biology

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)