Can I read Working goal of Brazilein sappan wood as a candidate for SARS-coV-2 antivirus drug against spike (S) glycoprotein, papain-like proteinase, and main protease: In silico study on EtoBox?
Working goal of Brazilein sappan wood as a candidate for SARS-coV-2 antivirus drug against spike (S) glycoprotein, papain-like proteinase, and main protease: In silico study by Ira Arundina; TheresiaIndah Budhy; WisnuSetyari Juliastuti; MeircuriusDwi Condro Surboyo; AnisaNur Halimah; Putrisa Lestari is a Dentistry article available to read on EtoBox.
What is Working goal of Brazilein sappan wood as a candidate for SARS-coV-2 antivirus drug against spike (S) glycoprotein, papain-like proteinase, and main protease: In silico study about?
Brazilein sappan wood, played by Spike (S) glycoprotein, Papain-Like proteinase (PLpro), and Main protease (Mpro), is expected to be a candidate for the antiviral drug SARS-CoV-2, which can inhibit viral attachment to the human body, replication, and transcription processes. The aim of this study was to predict __in silico__, using the comparative drug hydroxychloroquine, the working goal of brazilein sappan wood as a candidate for the antiviral drug SARS-CoV-2 against protein S, PLpro, and Mpro. The approach used is the __in silico__ docking test using the computer program Molegro Virtual Docker. Receptor used by protein S, Protein Data Bank (PDB) code: 6M0J, NAG\_601[E] ligand; PLpro, PDB code: 7JIT, Y95\_501[A] ligand; and Mpro, PDB code: 1WOF, I12\_1145[A] ligand. Data analysis was carried out by comparing the docking bond energies between the ligands at the target receptor. Silico test results for protein S: ligand bond energy NAG\_601 [E] = −59.4555, brazilein = −71.5537, hydroxychloroquine = −79.3704; PLpro protein: Ligand bond energy Y95\_501 [A] = −129.561, brazilein = −94.9761, hydroxychloroquine = −100.984; Mpro protein: Ligand bond energy I12 1145 [A] = −141.135, brazil
Who reads Working goal of Brazilein sappan wood as a candidate for SARS-coV-2 antivirus drug against spike (S) glycoprotein, papain-like proteinase, and main protease: In silico study?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Ira Arundina; TheresiaIndah Budhy; WisnuSetyari Juliastuti; MeircuriusDwi Condro Surboyo; AnisaNur Halimah; Putrisa Lestari
- Publisher
- Medknow
- Published
- 2021
- Language
- EN
- Field
- Dentistry (Health Sciences)