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Significant improvement in treatment resistant auditory verbal hallucinations after 5 days of double-blind, randomized, sham controlled, fronto-temporal, transcranial direct current stimulation (tDCS): A replication/extension study by Joshua T. Kantrowitz; Pejman Sehatpour; Michael Avissar; Guillermo Horga; Anna Gwak; Mathew J. Hoptman; Odeta Beggel; Ragy R. Girgis; Blair Vail; Gail Silipo; Marlene Carlson; Daniel C. Javitt is a Neuroscience article available to read on EtoBox.

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## Background: Transcranial direct current stimulation (tdcs) is a potentially novel treatment for antipsychotic-resistant auditory verbal hallucinations (avh) in schizophrenia. nevertheless, results have been mixed across studies. ## Methods: 89 schizophrenia/schizoaffective subjects (active: 47; sham: 42) were randomized to five days of twice-daily 20-min active tdcs vs. sham treatments across two recruitment sites. avh severity was assessed using the auditory hallucination rating scale (ahrs) total score. to assess target engagement, mri was obtained in a sub sample. ## Results: We observed a statistically significant, moderate effect-size change in ahrs total score across one-week and one-month favoring active treatment following covariation for baseline symptoms and antipsychotic dose (p = 0.036; d = 0.48). greatest change was observed on the ahrs loudness item (p = 0.003; d = 0.69). in exploratory analyses, greatest effects on ahrs were observed in patients with lower cognitive symptoms (d = 0.61). in target engagement analysis, suprathreshold mean field-strength (>0.2 v/m) was seen within language-sensitive regions. however, off-target field-strength, which correlated signif

Who reads Significant improvement in treatment resistant auditory verbal hallucinations after 5 days of double-blind, randomized, sham controlled, fronto-temporal, transcranial direct current stimulation (tDCS): A replication/extension study?

Author

Joshua T. Kantrowitz; Pejman Sehatpour; Michael Avissar; Guillermo Horga; Anna Gwak; Mathew J. Hoptman; Odeta Beggel; Ragy R. Girgis; Blair Vail; Gail Silipo; Marlene Carlson; Daniel C. Javitt

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Neuroscience (Life Sciences)