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Cerebellar Presentation of Multiple System Atrophy by G. K. Wenning; E. Kraft; R. Beck; C. J. Fowler; C. J. Mathias; Dr. N. P. Quinn; A. E. Harding is a Medicine article available to read on EtoBox.

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## Abstract Early diagnosis of multiple‐system atrophy (MSA) is important in patients presenting with late‐onset cerebellar ataxia because it has a less favourable prognosis than other degenerative ataxic disorders. We report cerebellar presentation of MSA in a series of 16 patients, 3 of whom later developed parkinsonism. Two‐thirds of them had early evidence of impaired postural reflexes with a history of recurrent falls. Some of these had a narrow‐based, unsteady gait, unlike the more classic broad‐based gait ataxia of cerebellar disease. On review of the patients' histories, genitourinary dysfunction (particularly impotence) was present at the onset of, or preceding, cerebellar ataxia in 60% of patients, but this had often been attributed to age, or to urological or gynaecological causes. External striated anal or urethral sphincter electromyography (EMG) demonstrated features of chronic denervation and reinnervation in 14 (93%) of 15 patients, consistent with degeneration in Onuf's nucleus as occurs in MSA. Autonomic function tests were abnormal in 9 (64%) of 14 patients. Our data suggest that close enquiry into genitourinary function and analysis of the gait disorder can be u

Who reads Cerebellar Presentation of Multiple System Atrophy?

Author

G. K. Wenning; E. Kraft; R. Beck; C. J. Fowler; C. J. Mathias; Dr. N. P. Quinn; A. E. Harding

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1997

Language

EN

Field

Medicine (Health Sciences)