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Ganglioside binding pattern of CD33-related siglecs by Eugenia Rapoport; Ilya Mikhalyov; Jiquan Zhang; Paul Crocker; Nicolai Bovin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Ganglioside binding pattern of CD33-related siglecs about?

Our study deals with the interaction of CD33 related-siglecs-5,-7,-8,-9,-10 with gangliosides GT1b, GQ1b, GD3, GM2, GM3 and GD1a. Siglec-5 bound preferentially to GQ1b, but weakly to GT1b, whereas siglec-10 interacted only with GT1b ganglioside. Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3. Siglec-8 demonstrated low affinity to the gangliosides tested compared with other siglecs. Despite high structural similarity of CD33 related siglecs, they demonstrated different ganglioside selectivity, in particular to the Neu5Acalpha2-8Neu5Ac motif.

Who reads Ganglioside binding pattern of CD33-related siglecs?

Author

Eugenia Rapoport; Ilya Mikhalyov; Jiquan Zhang; Paul Crocker; Nicolai Bovin

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)