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Lubrication Properties of Potential Alternative Lubricants, Glycerin Fatty Acid Esters, to Magnesium Stearate by Takeaki Uchimoto; Yasunori Iwao; Yuki Ikegami; Takashi Murata; Takashi Sonobe; Atsuo Miyagishima; Shigeru Itai is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-3.0%, the increase in the pressure transmission ratio that was equal to or greater than that of Mg-St as well as the reduction in the ejection force was observed at a low concentration in both TR-FB and TR-HB, proving that they have excellent lubrication performance. The granules that were lubricated with TR-FB and TR-HB at even low concentration of 0.4% showed a more stable and sufficiently lower ejection force than with Mg-St from the first tablet after the start of compression. When they were mixed for 5-60 min, while the mixture with Mg-St showed a low pressure transmission ratio of 82% and a high ejection force of 500 N in the first tablet even when the mixing time was 60 min, a high pressure transmission ratio and a low ejection force were observed in TR-FB and TR-HB from the first tablet after mixing for 5-60 min, and these were maintained thereafter. As for the

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Author

Takeaki Uchimoto; Yasunori Iwao; Yuki Ikegami; Takashi Murata; Takashi Sonobe; Atsuo Miyagishima; Shigeru Itai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2010

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)