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Can I read Cotranslational Sorting and Processing of Newly Synthesized Proteins in Eukaryotes on EtoBox?
Cotranslational Sorting and Processing of Newly Synthesized Proteins in Eukaryotes by Martin Gamerdinger; Elke Deuerling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cotranslational Sorting and Processing of Newly Synthesized Proteins in Eukaryotes about?
Ribosomes interact with a variety of different protein biogenesis factors that guide newly synthesized proteins to their native 3D shapes and cellular localization. Depending on the type of translated substrate, a distinct set of cotranslational factors must interact with the ribosome in a timely and coordinated manner to ensure proper protein biogenesis. While cytonuclear proteins require cotranslational maturation and folding factors, secretory proteins must be maintained in an unfolded state and processed cotranslationally by transport and membrane translocation factors. Here we explore the specific cotranslational processing steps for cytonuclear, secretory, and membrane proteins in eukaryotes and then discuss how the nascent polypeptide-associated complex (NAC) cotranslationally sorts these proteins into the correct protein biogenesis pathway.
Who reads Cotranslational Sorting and Processing of Newly Synthesized Proteins in Eukaryotes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Martin Gamerdinger; Elke Deuerling
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)