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Testosterone Replacement Therapy Improves Metabolic Parameters in Hypogonadal Men with Type 2 Diabetes but Not in Men with Coexisting Depression: The BLAST Study by Geoffrey Hackett; Nigel Cole; Mithun Bhartia; David Kennedy; Jessie Raju; Peter Wilkinson; the BLAST Study Group is a Medicine article available to read on EtoBox.
What is Testosterone Replacement Therapy Improves Metabolic Parameters in Hypogonadal Men with Type 2 Diabetes but Not in Men with Coexisting Depression: The BLAST Study about?
## Introduction: The association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established and current endocrine society guidelines recommend the measurement of testosterone levels in all men with type 2 diabetes or erectile dysfunction. ## Aim: We report the first double-blind, placebo-controlled study conducted exclusively in a male type 2 diabetes population to assess metabolic changes with long-acting testosterone undecanoate (tu). ## Methods: The type 2 diabetes registers of seven general practices identified 211 patients for a 30-week double-blind, placebo-controlled study of long-acting tu 1,000 mg followed by 52 weeks of open-label use. because of the established impact of age, obesity, and depression on sexual function, these variables were also assessed for influence on metabolic parameters. ## Main outcome measure: Changes in glycated hemoglobin (hba1c) and the level of testosterone at which response are achieved. ## Results: Treatment with tu produced a statistically significant reduction in hba1c at 6 and 18 weeks and after a further 52 weeks of open-label medication most marked in poorly controlled patients with baseline hb
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Geoffrey Hackett; Nigel Cole; Mithun Bhartia; David Kennedy; Jessie Raju; Peter Wilkinson; the BLAST Study Group
- Publisher
- Oxford University Press (OUP)
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)