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Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder by Maria Meehan; Audrey Melvin; Emma Gallagher; James Smith; Alo Mc Goldrick; Catherine Moss; Steven Goossens; Michèle Harrison; Elaine Kay; John Fitzpatrick; Peter Dervan; Amanda Mc Cann is a Medicine article available to read on EtoBox.

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## Abstract __CTNNA3__ (alpha‐T‐catenin) is imprinted with preferential monoallelic expression of the maternal allele in placental tissue. The allelic expression pattern of __CTNNA3__ in adult human cancer is unknown and warrants investigation as __CTNNA3__ stabilizes cellular adherence, a feature which if compromised could enable cells to acquire an increased capability to detach and invade. We document the frequency of monoallelic versus biallelic expression of __CTNNA3__ in urothelial carcinoma of the bladder (UCB) samples and compare the observed patterns with that found in the paired normal sample. DNA PCR reactions encompassing a transcribable SNP polymorphism within exon 12 of __CTNNA3__ were sequence analyzed to identify heterozygous cases. A total of 96 samples were analyzed and included 22 paired normal and tumor UCB cases, 38 formalin fixed paraffin embedded (FFPE) UCB samples consisting of 18 noninvasive pTa tumors and 20 lamina propria invasive pT1 tumors and 14 cell lines of various lineages. RT‐PCR analysis of 35 heterozygous samples followed by sequence analysis allowed monoallelic versus biallelic patterns to be assigned. We have provided the first demonstration th

Who reads Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder?

Author

Maria Meehan; Audrey Melvin; Emma Gallagher; James Smith; Alo Mc Goldrick; Catherine Moss; Steven Goossens; Michèle Harrison; Elaine Kay; John Fitzpatrick; Peter Dervan; Amanda Mc Cann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2007

Language

EN

Field

Medicine (Life Sciences)