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Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer’s dementia in mild cognitive impairment patients by Alexa Pichet Binette; Sebastian Palmqvist; Divya Bali; Gill Farrar; Christopher J. Buckley; David A. Wolk; Henrik Zetterberg; Kaj Blennow; Shorena Janelidze; Oskar Hansson is a Medicine article available to read on EtoBox.
What is Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer’s dementia in mild cognitive impairment patients about?
## Abstract ## Background Up to now, there are no clinically available minimally invasive biomarkers to accurately identify mild cognitive impairment (MCI) patients who are at greater risk to progress to Alzheimer’s disease (AD) dementia. The recent advent of blood-based markers opens the door for more accessible biomarkers. We aimed to identify which combinations of AD related plasma biomarkers and other easily accessible assessments best predict progression to AD dementia in patients with mild cognitive impairment (MCI). ## Methods We included patients with amnestic MCI (n = 110) followed prospectively over 3 years to assess clinical status. Baseline plasma biomarkers (amyloid-β 42/40, phosphorylated tau217 [p-tau217], neurofilament light and glial fibrillary acidic protein), hippocampal volume, APOE genotype, and cognitive tests were available. Logistic regressions with conversion to amyloid-positive AD dementia within 3 years as outcome was used to evaluate the performance of different biomarkers measured at baseline, used alone or in combination. The first analyses included only the plasma biomarkers to determine the ones most related to AD dementia conversion. Second, hippoca
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- Author
- Alexa Pichet Binette; Sebastian Palmqvist; Divya Bali; Gill Farrar; Christopher J. Buckley; David A. Wolk; Henrik Zetterberg; Kaj Blennow; Shorena Janelidze; Oskar Hansson
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)