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Can I read Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine on EtoBox?
Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine by S. Ilbeigi; A. Ranjbar; N. Zahraie; R. Dehdari Vais; M. Rafiee Monjezi; N. Sattarahmady is a Materials Science article available to read on EtoBox.
What is Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine about?
As an innovative treatment strategy to overcome solid tumors, sonodynamic therapy (SDT) comprises low-intensity ultrasound (US) radiation by using a sonosensitizer and includes considerable advantages, compared to other traditional methods to establish potential treatments such as deeper tumor destruction, targeted uptake of chemotherapeutic drugs, minor side effects and lower invasiveness. In this study, we synthesized and characterized selenium-polyethylene glycol-curcumin nanoparticles (Se-PEG-Cur NPs) as a new sonosensitizer with the ability of ultrasonic waves absorption. Cytotoxicity of Se-PEG-Cur NPs was compared with gemcitabine (GEM) as the first-line treatment of pancreatic cancer. ASPC1 cell line was treated with both Se-PEG-Cur NPs and GEM separately as well as their combination without or with US radiation. Effect of US radiation on cytotoxicity of Se-PEG-Cur NPs, GEM and their combination was evaluated through evaluation of cells viability, measurement of reactive oxygen species (ROS) level, and estimation of apoptosis promotion. The results revealed that cells SDT using Se-PEG-Cur NPs, GEM and their combination went mainly with ROS production and induced apoptosis in
Who reads Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- S. Ilbeigi; A. Ranjbar; N. Zahraie; R. Dehdari Vais; M. Rafiee Monjezi; N. Sattarahmady
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)