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Metabolic Characterization of Plasma and Cyst Fluid from Cystic Precursors to Pancreatic Cancer Patients Reveal Metabolic Signatures of Bacterial Infection by Ann Morgell; Julie A. Reisz; Zeeshan Ateeb; Haleh Davanian; Susanne E. Reinsbach; Asif Halimi; Rogier Gaiser; Roberto Valente; Urban Arnelo; Marco Del Chiaro; Margaret Sällberg Chen; Angelo D’Alessandro is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Metabolic Characterization of Plasma and Cyst Fluid from Cystic Precursors to Pancreatic Cancer Patients Reveal Metabolic Signatures of Bacterial Infection about?

Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5 year survival rate as low as 9%. One factor complicating the management of pancreatic cancer is the lack of reliable tools for early diagnosis. While up to 50% of the adult population has been shown to develop precancerous pancreatic cysts, limited and insufficient approaches are currently available to determine whether a cyst is going to progress into pancreatic cancer. Recently, we used metabolomics approaches to identify candidate markers of disease progression in patients diagnosed with intraductal papillary mucinous neoplasms (IPMNs) undergoing pancreatic resection. Here, we enrolled an independent cohort to verify the candidate markers from our previous study with orthogonal quantitative methods in plasma and cyst fluid from serous cystic neoplasm and IPMN (either low-or high-grade dysplasia or pancreatic ductal adenocarcinoma). We thus validated these markers with absolute quantitative methods through the auxilium of stable isotope-labeled internal standards in a new independent cohort. Finally, we identified novel markers of IPMN status and disease progressionincluding amino acids, c

Who reads Metabolic Characterization of Plasma and Cyst Fluid from Cystic Precursors to Pancreatic Cancer Patients Reveal Metabolic Signatures of Bacterial Infection?

Author

Ann Morgell; Julie A. Reisz; Zeeshan Ateeb; Haleh Davanian; Susanne E. Reinsbach; Asif Halimi; Rogier Gaiser; Roberto Valente; Urban Arnelo; Marco Del Chiaro; Margaret Sällberg Chen; Angelo D’Alessandro

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)