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A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia by Osmanova, Diana Z.; Freidin, Maxim B.; Fedorenko, Olga Yu.; Pozhidaev, Ivan V.; Boiko, Anastasiia S.; Vyalova, Natalia M.; Tiguntsev, Vladimir V.; Kornetova, Elena G.; Loonen, Anton J. M.; Semke, Arkadiy V.; Wilffert, Bob; Bokhan, Nikolay A.; Ivanova, Svetlana A. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: Hyperprolactinemia (hprl) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine d2 receptors (drd2s) on the membranes of lactotroph cells within the pituitary gland. certain antipsychotic drugs, e.g. risperidone, are more likely to induce hprl because of relative accumulation within the adenohypophysis. nevertheless, due to competition for pituitary drd2s by high dopamine levels may limit antipsychotic-induced hprl. moreover, the activity of prolactin-producing lactotrophs also depends on other hormones which are regulated by the extra-pituitary activity of dopamine receptors, dopamine transporters, enzymes of neurotransmitter metabolism and other factors. polymorphic variants in the genes coding for these receptors and proteins can have functional significance and influence on the development of hyperprolactinemia. ## Methods: A set of 41 snps of genes for dopamine receptors drd1, drd2, drd3, drd4, the dopamine transporter slc6a3 and dopamine catabolizing enzymes maoa and maob was investigated in a population of 446 caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to icd-10: f20) with a

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Author

Osmanova, Diana Z.; Freidin, Maxim B.; Fedorenko, Olga Yu.; Pozhidaev, Ivan V.; Boiko, Anastasiia S.; Vyalova, Natalia M.; Tiguntsev, Vladimir V.; Kornetova, Elena G.; Loonen, Anton J. M.; Semke, Arkadiy V.; Wilffert, Bob; Bokhan, Nikolay A.; Ivanova, Svetlana A.

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)