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Can I read Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates on EtoBox?
Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates by Kevin C. Zhang; Nikhil Narang; Carine Jasseron; Richard Dorent; Kevin A. Lazenby; Mark N. Belkin; Jonathan Grinstein; Anoop Mayampurath; Matthew M. Churpek; Kiran K. Khush; William F. Parker is a Medicine article available to read on EtoBox.
What is Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates about?
## Importance The US heart allocation system prioritizes medically urgent candidates with a high risk of dying without transplant. The current therapy-based 6-status system is susceptible to manipulation and has limited rank ordering ability. ## Objective To develop and validate a candidate risk score that incorporates current clinical, laboratory, and hemodynamic data. ## Design, Setting, and Participants A registry-based observational study of adult heart transplant candidates (aged ≥18 years) from the US heart allocation system listed between January 1, 2019, and December 31, 2022, split by center into training (70%) and test (30%) datasets. Adult candidates were listed between January 1, 2019, and December 31, 2022. ## Main Outcomes and Measures A US candidate risk score (US-CRS) model was developed by adding a predefined set of predictors to the current French Candidate Risk Score (French-CRS) model. Sensitivity analyses were performed, which included intra-aortic balloon pumps (IABP) and percutaneous ventricular assist devices (VAD) in the definition of short-term mechanical circulatory support (MCS) for the US-CRS. Performance of the US-CRS model, French-CRS model, and 6-sta
Who reads Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kevin C. Zhang; Nikhil Narang; Carine Jasseron; Richard Dorent; Kevin A. Lazenby; Mark N. Belkin; Jonathan Grinstein; Anoop Mayampurath; Matthew M. Churpek; Kiran K. Khush; William F. Parker
- Publisher
- American Medical Association (AMA)
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)