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Can I read Genetic engineering of Bacillus subtilis for the commercial production of riboflavin on EtoBox?
Genetic engineering of Bacillus subtilis for the commercial production of riboflavin by J B Perkins; A Sloma; T Hermann; K Theriault; E Zachgo; T Erdenberger; N Hannett; N P Chatterjee; V Williams II; GA Rufo Jr; R Hatch; J Pero is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genetic engineering of Bacillus subtilis for the commercial production of riboflavin about?
Recombinant DNA engineering was combined with mutant selection and fermentation improvement to develop a strain of Bacillus subtilis that produces commercially attractive levels of riboflavin. The B. subtilis riboflavin production strain contains multiple copies of a modified B. subtilis riboflavin biosynthetic operon (rib operon) integrated at two different sites in the B. subtilis chromosome. The modified rib operons are expressed constitutively from strong phage promoters located at the 5′ end and in an internal region of the operon. The engineered strain also contains purine analog-resistant mutations designed to deregulate the purine pathway (GTP is the precursor for riboflavin), and a riboflavin analog-resistant mutation in ribC that deregulates the riboflavin biosynthetic pathway.
Who reads Genetic engineering of Bacillus subtilis for the commercial production of riboflavin?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- J B Perkins; A Sloma; T Hermann; K Theriault; E Zachgo; T Erdenberger; N Hannett; N P Chatterjee; V Williams II; GA Rufo Jr; R Hatch; J Pero
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)