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Generation of CD4^+^ cytotoxic T lymphocytes stimulated by immobilized anti‐CD3 monoclonal antibody and interleukin‐2 in cancer patients by Masaji Tani; Hiroshi Tammura; Hiroki Yamaue; Shizuma Mizobata; Makoto Iwahashi; Takuya Tsunoda; Kohci Noguchi; Mikiko Tamai; Tsukasa Hotta; Hiroshi Terasawa; Kazuo Arii is a Medicine article available to read on EtoBox.
What is Generation of CD4^+^ cytotoxic T lymphocytes stimulated by immobilized anti‐CD3 monoclonal antibody and interleukin‐2 in cancer patients about?
The proliferation of autologous tumor-reactive cytotoxic T lymphocytes (CTL), induced by autologous mixed lymphocyte tumor-cell culture, was remarkably enhanced by activation with immobilized anti-CD3 monoclonal antibody (MAb) and interleukin-2 (IL-2), as compared with IL-2 alone. The activated CTL exhibited high cytotoxicity against autologous tumor cells. Cytotoxicity against autologous tumor cells was inhibited by anti-HIA-DR MAb. In negative selection with immunomagnetic beads, cytotoxicity against autologous tumor cells was inhibited by the elimination of CD4+ cells. The major cell-surface antigens of the activated CTL were CD3+, CD4+, CD25+, CD45RO+ and CD45RA-, suggesting helper T cells, and the activated CTL produced IL-2. It is concluded that the CTL activated by immobilized anti-CD3 MAb and IL-2 were CD4 cells that had both killer and helper functions. Our findings indicate that adoptive immunotherapy using these activated CTL would be effective in cancer patients.
Who reads Generation of CD4^+^ cytotoxic T lymphocytes stimulated by immobilized anti‐CD3 monoclonal antibody and interleukin‐2 in cancer patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Masaji Tani; Hiroshi Tammura; Hiroki Yamaue; Shizuma Mizobata; Makoto Iwahashi; Takuya Tsunoda; Kohci Noguchi; Mikiko Tamai; Tsukasa Hotta; Hiroshi Terasawa; Kazuo Arii
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)