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Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil by Maria Cassia Mendes-Correa; João RR Pinho; Michele S Gomes-Gouvea; Adriana C da Silva; Cristina F Guastini; Luiz G Martins; Andréa G Leite; Mariliza H Silva; Reinaldo J Gianini; David E Uip is a Medicine article available to read on EtoBox.
What is Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil about?
## Background HBV-HIV co-infection is associated with an increased liver-related morbidity and mortality. However, little is known about the natural history of chronic hepatitis B in HIV-infected individuals under highly active antiretroviral therapy (HAART) receiving at least one of the two drugs that also affect HBV (TDF and LAM). Information about HBeAg status and HBV viremia in HIV/HBV co-infected patients is scarce. The objective of this study was to search for clinical and virological variables associated with HBeAg status and HBV viremia in patients of an HIV/HBV co-infected cohort. ## Methods A retrospective cross-sectional study was performed, of HBsAg-positive HIV-infected patients in treatment between 1994 and 2007 in two AIDS outpatient clinics located in the São Paulo metropolitan area, Brazil. The baseline data were age, sex, CD4 T+ cell count, ALT level, HIV and HBV viral load, HBV genotype, and duration of antiretroviral use. The variables associated to HBeAg status and HBV viremia were assessed using logistic regression. ## Results A total of 86 HBsAg patients were included in the study. Of these, 48 (56%) were using combination therapy that included lamivudine (LA
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- Author
- Maria Cassia Mendes-Correa; João RR Pinho; Michele S Gomes-Gouvea; Adriana C da Silva; Cristina F Guastini; Luiz G Martins; Andréa G Leite; Mariliza H Silva; Reinaldo J Gianini; David E Uip
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)