Can I read Nucleosides and Nucleotides. 153. Effects of 2′-α- and 2′-β-Bromo-2′-deoxyadenosine on Oligonucleotide Hybridization and Nuclease Stability on EtoBox?

Nucleosides and Nucleotides. 153. Effects of 2′-α- and 2′-β-Bromo-2′-deoxyadenosine on Oligonucleotide Hybridization and Nuclease Stability by Mitsutoshi Aoyagi; Yoshihito Ueno; Akira Ono; Akira Matsuda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nucleosides and Nucleotides. 153. Effects of 2′-α- and 2′-β-Bromo-2′-deoxyadenosine on Oligonucleotide Hybridization and Nuclease Stability about?

l-(2-Bromo-2-deoxy-l~-D-ribofuranosyl)adenine (1) and l-(2-bromo-2-deoxy-~-D-arabinofuranosyl)adenine (2) were incorporated into DNA pentadecamers. The oligonucleotides containing I destabilized DNA/DNA and DNA/RNA duplex formation. However, the oligonucleotides containing 2 slightly stabilized DNA/DNA duplex formation, although they decreased the stability of DNA/RNA duplexes. Furthermore. the oligonucleotide containing 2 was more resistant to snake venom phosphodiesterase than an unmodified oligonucleotide (dA)t~ and the oligonucleotide containing 1.

Who reads Nucleosides and Nucleotides. 153. Effects of 2′-α- and 2′-β-Bromo-2′-deoxyadenosine on Oligonucleotide Hybridization and Nuclease Stability?

Author

Mitsutoshi Aoyagi; Yoshihito Ueno; Akira Ono; Akira Matsuda

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)