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Can I read Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists on EtoBox?
Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists by Benjamin J. Huffman; Shuming Chen; J. Luca Schwarz; R. Erik Plata; Emily N. Chin; Luke L. Lairson; K. N. Houk; Ryan A. Shenvi is a Chemistry article available to read on EtoBox.
What is Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists about?
olecular libraries play an integral role in drug development. Some libraries, however, are superior to others, as defined by their success in high-throughput screens or clinical progression 1 . Natural product-like attributes, earmarked as desirable 2,3 , can lead to higher hit rates, higher selectivity 4 and lower toxicity-related attrition, whereas classically flat libraries show promiscuity 5 . Traditional synthetic libraries can be distinguished from natural product collections by their low number of stereocentres per molecule, high aromatic ring content and low fraction of sp 3 -hybridized atoms (Fsp 3 ) 6,7 . With respect to ring connectivity (Fig. 1a), this difference is illustrated by the abundance in screening sets of biaryl motifs that are formed by sp 2 -sp 2 cross-coupling methods (Fig. 1b) [8][9][10] . The tetrahedral equivalent (sp 3 -hybridized attached-rings 5 ) are instead found in collections of isolates (Fig. 1c). Synthetic libraries lack similar motifs because few methods can link fully substituted carbon atoms of two rings with stereocontrol 11,12 . This is occasionally referred to as the attachedring problem 5,[13][14][15][16] . We report an unusual butenolide
Who reads Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Benjamin J. Huffman; Shuming Chen; J. Luca Schwarz; R. Erik Plata; Emily N. Chin; Luke L. Lairson; K. N. Houk; Ryan A. Shenvi
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1755-4330)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Physical Sciences)