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Prostate cancer risk‐associated variants reported from genome‐wide association studies: Meta‐analysis and their contribution to genetic Variation by Seong‐Tae Kim; Yu Cheng; Fang‐Chi Hsu; Tao Jin; A. Karim Kader; S. Lilly Zheng; William B. Isaacs; Jianfeng Xu; Jielin Sun is a Medicine article available to read on EtoBox.
What is Prostate cancer risk‐associated variants reported from genome‐wide association studies: Meta‐analysis and their contribution to genetic Variation about?
## Abstract ## BACKGROUND Genome‐wide association studies (GWAS) have led to the discovery of multiple single nucleotide polymorphisms (SNPs) that are associated with prostate cancer (PCa) risk. These SNPs may potentially be used for risk prediction. To date, there is not a stable estimate of their effect on PCa risk and their contribution to the genetic variation both of which are important for future risk prediction. ## METHODS A literature review was conducted to identify SNPs associated with PCa risk with the following criteria: (1) GWAS in the Caucasian population; (2) SNPs with __P__‐value <1.0 × 10^−6^; and (3) one SNP from each independent LD block. A meta‐analysis was performed to estimate combined odds ratio (OR) and its 95% confidence interval (CI) for the identified SNPs. The proportion of total genetic variance that is attributable by each of these SNPs was also estimated. ## RESULTS Thirty PCa risk‐associated SNPs were identified. These SNPs had OR estimates between 1.12 and 1.47 except for marker rs16901979 (OR = 1.80). Significant heterogeneity in OR estimates was found among different studies for 13 SNPs. The proportion of total genetic variance attributed by each
Who reads Prostate cancer risk‐associated variants reported from genome‐wide association studies: Meta‐analysis and their contribution to genetic Variation?
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- Author
- Seong‐Tae Kim; Yu Cheng; Fang‐Chi Hsu; Tao Jin; A. Karim Kader; S. Lilly Zheng; William B. Isaacs; Jianfeng Xu; Jielin Sun
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)