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Pediatric brain tumors: genetics and clinical outcome: Clinical article by Claudia Faria; José Miguéns; João Lobo Antunes; Duarte Salgado; Sofia Nunes; Cândida Barroso; Maria do Carmo Martins; Vasco Moura Nunes; Lúcia Roque is a Medicine article available to read on EtoBox.

What is Pediatric brain tumors: genetics and clinical outcome: Clinical article about?

## Object In this paper the authors' goal was to investigate the genetic characteristics of primary brain tumors in children and determine their influence on clinical outcome. ## Methods The authors performed high-resolution comparative genomic hybridization studies in 14 low-grade and 12 high-grade brain neoplasms in 26 children who underwent surgery between 2005 and 2007. ## Results Complex comparative genomic hybridization alterations were observed in 2 (14.3%) of the 14 lowgrade lesions and in 8 (66.6%) of the 12 high-grade lesions. High-level amplifications of DNA were detected in 3 cases, namely in a desmoplastic medulloblastoma where a __c-Myc__ amplification was found. Gains of 1q were detected in 2 low-grade and 6 high-grade lesions that were classified as ependymomas, astrocytomas, oligodendrogliomas, oligoastrocytomas, and gangliogliomas. When the authors correlated genetics with outcome, they noted that among the low-grade neoplasms only the 2 patients who presented with complex comparative genomic hybridization alterations had to undergo reoperation because of recurrent disease. The patient with __c-Myc__ amplification died of progressive disease. Gains of 1q were only

Who reads Pediatric brain tumors: genetics and clinical outcome: Clinical article?

Author

Claudia Faria; José Miguéns; João Lobo Antunes; Duarte Salgado; Sofia Nunes; Cândida Barroso; Maria do Carmo Martins; Vasco Moura Nunes; Lúcia Roque

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Published

2010

Language

EN

Field

Medicine (Health Sciences)