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Mosaic Pattern of Gliosis in the Neostriatum of a North American Man with Craniocervical Dystonia and Parkinsonism by Dr. Stewart A. Factor; Kevin D. Barron is a Medicine article available to read on EtoBox.

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## Abstract We present the case of a 51‐year‐old patient with a 31‐year history of psychiatric symptoms, craniocervical dystonia, bulbar dysfunction, and parkinsonism. His dystonic movements included blepharospasm, jaw opening and lingual dystonia, and spasmodic retrocollis. Psychiatric symptoms included psychosis and depression, with onset years before the movement disorder. After his death by aspiration, examination of his brain revealed abnormalities limited to the neostriatum. Staining of brain sections, including Holzer, glial fibrillary acidic protein, and immunohistochemical stain for calbindin D28k, revealed the presence of a mosaic pattern of gliosis with neuronal loss (sparing large neurons) within this region. The islands of tissue between strands of gliosis had a normal appearance. This patient represents only the fourth case (and first North American born) with a mosaic pattern of gliosis in the neostriatum. The clinical and pathologic features were similar in all four cases except that our patient was the first with prominent psychiatric symptoms and a more stable, less progressive course. Mosaicism has been described in the X‐linked Filipino disorder __Lubag__. Occur

Who reads Mosaic Pattern of Gliosis in the Neostriatum of a North American Man with Craniocervical Dystonia and Parkinsonism?

Author

Dr. Stewart A. Factor; Kevin D. Barron

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1997

Language

EN

Field

Medicine (Health Sciences)