About this document
Iron Storage and Regulation in the Body by Murtadha Alrubaye is a document available to read on EtoBox.
Hepcidin plays a central role in regulating iron metabolism. It is a peptide hormone that binds to ferroportin, the only cellular iron exporter, forming a complex that is degraded in lysosomes. This causes iron to be retained in cells rather than exported into plasma. By decreasing ferroportin levels on enterocytes, hepatocytes and macrophages, hepcidin lowers iron absorption and release, decreasing serum iron levels. Hepcidin levels are increased by factors like inflammation and erythropoiesis and decrease
- Author
- Murtadha Alrubaye
- Language
- EN