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Functional Properties of the Superior Vena Cava (SVC)-Aorta Ganglionated Plexus: Evidence Suggesting an Autonomic Basis for Rapid SVC Firing by ZHIBING LU; BENJAMIN J. SCHERLAG; GUODONG NIU; JIAXIONG LIN; KAR-MING FUNG; LICHAO ZHAO; LILEI YU; WARREN M. JACKMAN; RALPH LAZZARA; HONG JIANG; SUNNY S. PO is a Medicine article available to read on EtoBox.

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## Introduction: The mechanism underlying spontaneous rapid superior vena cava (svc) firing that initiates atrial fibrillation (af) remains poorly understood. we investigated the role of the svc-aorta-ganglionated plexus (svc-ao-gp) in af initiated by rapid firing from the svc. ## Methods and results: In 42 dogs, a circular catheter was positioned above the svc-atrial junction. multielectrode catheters were sutured on atria, atrial appendages and pulmonary veins. the effective refractory period (erp) and window of vulnerability (wov) for af were measured at all sites in the baseline state, during cervical vagosympathetic trunk stimulation and during svc-ao-gp stimulation, before and after svc-ao-gp ablation. af inducibility was also assessed by delivering high-frequency stimulation (hfs) within myocardial refractory period to the svc before and after svc-ao-gp ablation. hfs applied to the svc-ao-gp slowed the sinus rate and/or atrioventricular conduction. hfs of the svc-ao-gp induced more significant shortening of erp and a greater increase in wov at the svc than other sites. ablation of the svc-ao-gp significantly increased the baseline erp and decreased the baseline wov only at t

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Author

ZHIBING LU; BENJAMIN J. SCHERLAG; GUODONG NIU; JIAXIONG LIN; KAR-MING FUNG; LICHAO ZHAO; LILEI YU; WARREN M. JACKMAN; RALPH LAZZARA; HONG JIANG; SUNNY S. PO

Publisher

Wiley

Published

2010

Language

EN

Field

Medicine (Health Sciences)